Nigericin Facts Sheet (main)

This mini website about Nigericin was prepared by a student of BioInformatics, the Open University.

alternate names: Nigericin Polyetherin A, Azalomycin, Helixin C

from: ...Water-insoluble polyether antibiotic and ionophore. Stimulates ATPase activity in mitochondria. Active as ionophore for monovalent cations in mitochondria. Active against gram positive bacteria. Inhibitor of Golgi functions.... 

References: 
1. Pressman, B.C. (1976) Annu. Rev. Biochem. 45, 501-30 
2. Reed, P.W. (1979) Meth. Enzymol. LV, 435-54 
3. Seglen, P.O. (1983) Meth. Enzymol. 96, 737-64 
4. Zoratti, M. et al. (1984) Biochem. Biophys. Acta 767, 231-9

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source:  Nigericin is another ionophore that permits neutral (1:1) K⁺/H⁺ exchange across a membrane. Hence unlike valinomycin that can dissipate ΔΨ, nigericin does not affect ΔΨ but it will replace ΔpH.

 the 10 selected Nigericin abstracts

1	Nigericin inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes.
2	Nigericin inhibits accumulation of the steroidogenic acute regulatory protein but not steroidogenesis.
3	Studies on the prevention of nigericin action in neuroblastoma X glioma hybrid (NG108-15) cells.
4	Comparison of the effects of fluoride and the ionophore nigericin on acid production by Streptococcus mutans and the resultant in vitro enamel demineralization.
5	Metal ion specificity in anaesthetic induced increase in the rate of monensin and nigericin mediated H+/M+ exchange across phospholipid vesicular membranes.
6	Enhancement of the antifungal activity of rapamycin by the coproduced elaiophylin and nigericin.
7	Phosphorylation-dependent stimulation of prostanoid synthesis by nigericin in cerebral endothelial cells.
8	Effect of trace levels of nigericin on intracellular pH and acid-base transport in rat renal mesangial cells.
9	Activation of interleukin-1beta-converting enzyme by nigericin is independent of apoptosis.
10	Increased mature interleukin-1beta (IL-1beta) secretion from THP-1 cells induced by nigericin is a result of activation of p45 IL-1beta-converting enzyme processing.

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Brefeldin